Miarried to Mary Smith Sm6, sister of General Samuel Smith of Baltimore, Maryland, who also married a sister of George Nicholas Ni6 and Wilson Cary Nicholas Ni6.2, the latter married a sister of Mary Smith Sm6. so the children of each of these marriages were all double cousins of children of the other.

George Nicholas and Mary Smith had the following children:
Ni5-1 Col. Robert Carter Nicholas (1779 (?93 there is likely a confusion with a cousin of the same name who moved to New Orleans) - 1836 (?57), He was known as a brilliant talker.
Ni5-2 Maria Nicholas (1780 - ? ) 17 March 1804 married Col. Thomas D. Owings of Kentucky in Lexington Ky son of John Cockey Owings and Colegate Deye grandson of Joshua Owings Ow9-11 and grandnephew of Samuel Owings Ow9
Ni5-3 Smith Nicholas (1782 - ? )
Ni5-4 Ann Nicholas (1783 - ?)
Ni5-5 Sidney Nicholas (1785 - ? )
Ni5-6 Major Cary Nicholas (1786 - ? ) U.S. Army and great wit
Ni5-7 George Ann Nicholas (1788 - ?)
Ni5-8 Margarette Gailbraith Nicholas (1789 – Aug.13, 1819) married first Gen. J.C. Bartlett, second Gov. Thomas Fletcher, died without issue. She was portraited by Jewet; the portrait in the posession of Gen. Charles Parsons Nicholas Ni3-5-4 in 1975 and doublessly passed to his daughter, Frances.
Ni5-9 John Nelson Nicholas (1791 - 1826) ablest Journalist in Kentucky and in 1821 made Jefferson admit authorship of the Kentucky Resolution of 1798 with the further awowal that he wrote them at the insistance of George Nicholas (Ni6)
Ni5-10 Elizabeth Randolph Nicholas (1793 -) married James Gabriel Trotter of Lexington
Ni5-11 George Wilson Nicholas (1795 - ? )
Ni5 Samuel Smith Nicholas (1797 - 1869) He was the only son to marry.
Ni5-13 Henrietta (Hetty) Morrison Nicholas (1798 - ? ) married Richard Hawes Jr. brother of Albert Gallatin Hawes, nephew of Aylett Hawes, and cousin of Aylett Hawes Buckner, was born near Bowling Green, Caroline Co Va, Feb 1797. In 1824, Richard Hawes, Jr., removed to Winchester Ky, and practiced law. He represented that county in the legislature in 1828, 1829 and 1834, served in the Black Hawk War. He represented the Ashland District in Congress for four years--1837 to 1841. In 1843 he removed to Paris and continued to practice law until the fall of 1861. He took a leading part May 10-12, 1861, in efforts to harmonize in favor of an armed neutrality in the action of the state. Failing in this and becoming a mark for the bitterness of those who were inciting the military arrests in the fall of 1861, he took refuge in Virginia to escape imprisonment by the Federal authorities. Being too old--64 years--for active field duty, he was for eight or nine months brigade commissary in the Southern army.
?Ni5-14 Clara Nicholas, d unmarried

A key provision of the Kentucky Resolutions was Resolution 2, that denied Congress more than a few penal powers:

That the Constitution of the United States, having delegated to Congress a power to punish treason, counterfeiting the securities and current coin of the United States, piracies, and felonies committed on the high seas, and offenses against the law of nations, and no other crimes, whatsoever; and it being true as a general principle, and one of the amendments to the Constitution having also declared, that "the powers not delegated to the United States by the Constitution, not prohibited by it to the States, are reserved to the States respectively, or to the people," therefore the act of Congress, passed on the 14th day of July, 1798, and intituled "An Act in addition to the act intituled An Act for the punishment of certain crimes against the United States," as also the act passed by them on the -- day of June, 1798, intituled "An Act to punish frauds committed on the bank of the United States," (and all their other acts which assume to create, define, or punish crimes, other than those so enumerated in the Constitution,) are altogether void, and of no force; and that the power to create, define, and punish such other crimes is reserved, and, of right, appertains solely and exclusively to the respective States, each within its own territory.

He graduated at William and Mary College in 1772. At the beginning of Oct. 1775 he was commissioned to command a company of virginia troops in the Revolutionary War. There is a letter in the correspondence of Thomas Jefferson from Archibald Cary dated 31 Oct. 1775 saying: "...This Week past hosilitys Commenc'd in this Colony, by an Attack from the Navy on Hampton. Our Young Treasurer aided by Capt. Lynn behaved like Heroes of Old, but the Papers will Give you the Affaire at Large. ..." (Robert Carter Nicholas had long been called "The Old Treasurer" by his friends and colleagues, Archibald was his wife's cousin, plantation owner, Burgess and one of leading botanists of his day.)

When a young officer during the Revolutionary War George Nicholas met Mary Smith (Sm6) at a ball in Baltimore, and later married her. After resigning his commission he practiced law in Charlottesville, Albemarle County, Virginia, was a member of the Virginia legislature from Albemarle County. and became a leading member of the Virginia Convetion assembled for the consideration and adoption of the constitution of the federal Union,

He served as Captain and Major of the Second Virginia Regiment in 1777, and was made Colonel. He resigned after serving for two years.

George Nicholas (Ni6) was a member of the Virginia Convention that ratified the Federal Constitution. His speeches are recorded in Eliott' s Debates. He was a member of the Virginia House of Assembly and a Burgess.

In Wood's History of Albemarle, page 384, Appendix 7, George and Mary (Smith) Nicholas are listed as emigrants from Albemarle to other States. This was in 1790, when he moved Kentucky.

He there became the first Attorney-General of Kentucky, and was a member of the first Constitutional Convention at Danville in 1792.

In “Kentucky Lawyers and Lawmakers” on page 24, it says,   "a manuscript copy of this instrument (the first constitution) with corrections and notes in his own difficult chirography,  still in existence corroborates the statement that he was the author of the Constitution of Kentucky.”¬ “He was “the most active person compiling the sections of the constitution, which included many ideas developed in the Danville Political Club before his arrival in Kentucky (Kerr, Hist. of Kentucky, I pg 284; Durrett MS Collection)”

 George Nicholas (Ni6) established the Law Department at Transylvania University, Lexington, Kentucky and was its first Professor of Law.

  He lived between Lexington and Danville, and also in
 Lexington. Sayre College was at one time his residence.

“In July 1798 there was a gathering to discuss the Alien and Sedition Laws. Nicholas spoke out against them denouncing their anti-constitutional character, in the tumult that followed Henry Clay was called and his eloquent denunciation of the Federalist suppression so captivated the public that both were hoisted on the shoulder of the crowd and borne away as the heroes of the day (Kerr, History of Kentucky, I,pg. 410, Warfield, Ky. Res. Of 1798, Prentice, Biog. Of H. Clay)”
In the Public Library in Cincinnati, there is a printed  handbill, issued when he was making a campaign for Governor.  Colonel Nicholas died in July preceding the election.
  His burial place was an unmarked grave just inside the gate of the old Episcopal burial ground on Third Street in Lexington, Later a marker was put up by the Mt. Sterling DAR chapter, which is shown in the Lexington Leader issued June 21, 1957.

His obituary, published by John F. Bradford in the Kentucky Gazette, August 1, 1799, follows: "Departed this life, on the 25th ult. at his seat in this town, Colonel George Nicholas, Professor of Law and Politics in the
-'Transylvania University."
 " Vain would be the attempt to calculate the loss the
 - public has sustained in the death of Colonel Nicholas; the
  ability and sureness which has constantly displayed in his
efforts to delict and express every attempt to invade his Country's rights must endear him to recollection of every true republican: -and next to a numerous and affectionate family, the youth of Kentucky will long deplore the loss."

Sayre College