Po10 Nathaniel Pope II

    was born about 1635, son of Nathaniel Pope I and Luce ?Fox
    died between 1665 and 1675. .
    In, or about 1659 he married Mary Sisson Si10 who, after his death, married successively, William Bridges, Lewis Nicholas, David Wickcliffe/Whitcliffe and John Rosseer II.
    He lived in Westmoreland County, Virginia, on land inherited from his father.
    In 1661, January,3, he patented 1050 acres on Holle's Creek.

Nathaniel Pope and Mary Sisson had issue:
Po9 Nathaniel Pope III b about 1660

Evidently the "S" in her name in the sources was curved in such a way that it has often been mistaken for an "L", so many sources list her and her brother Daniel as Lisson. But this error has finally clarified by:
Judith Sisson Hynson
Director of Research & Library Collections
Stratford Hall

I am most grateful for this clarification.

Mary Sisson was presumably the daughter of Thomas Sisson, who arrived in Virginia in 1622 and had been a Haberdasher in London before that.
Her siblings were
-1 Capt John Sisson b about 1628,royal colonial army, married, probably in Virginia, Frances Gorsuch, daughter of Rev John Gorsuch. In 1659, John and his wife Frances immigrated to Maryland. In 1660 his daughter Joane was transported to Maryland. John Sison's will, probated 16 Mary 1663 in Anne Arundel County, names wife Frances, eldest daughter Jean Sison, daughter Eliza Sison, brother Benjamin Sison, brother Cornelius Howard (i.e., brother-in-law) . . . John's wife's Frances Gorsuch's sister Elizabeth Gorsuch Howard, the wife of Cornelius Howard. The land of Jane and Elizabeth SISSON is included in the Maryland Rent Rolls of Baltimore and Anne Arundel Counties in 1666 and 1667
-2 Robert Sisson, b about 1630 possibly the same as married Amye Wright
-3 Daniel Sisson b about 1632, resided in Westmoreland County. He received a bequest in the will of James Baldridge, dated Nov 28, 1658, probated Jan 10, 1659. Later he removed to Appomattox County.
-5 Nicholas Sisson b about 1637 married and among other children had a son who married into the famous French-Huguenot Muse family of Virginia, as did several generations of SISSONs thereafter. (Ref: Virginia Magazine of History and Biography, v 31, published by the Virginia Historical Society of Richmond, 1923)

Mary Sisson also had 3 children by her fourth marrige to David Wickliffe/Whitcliff:
Si10-2 David Whitcliff
Si10-3 Robert Whitcliff
Si10-4 Deborah Whitcliff